Cancer Prevention Science
From early detection technology to dietary interventions. Each graded by the quality of human evidence.
The Galleri Multi-Cancer Blood Test
Detects 50+ cancer types from a blood draw. PATHFINDER 2 trial: 7x cancer detection increase. The biggest shift in early detection in decades.
⭐ Grade A: Strong EvidenceHigh-Dose Melatonin
Meta-analysis of 8 RCTs: 34% cancer mortality reduction at 10-20mg nightly. No lethal dose ever established. $15/month.
🔬 Grade B: PromisingSulforaphane (Broccoli Sprouts)
Activates Nrf2 detox pathways. Phase II RCT signal in prostate cancer. 20-100x more potent in sprouts than mature broccoli.
🔬 Grade B: PromisingVitamin D3: The VITAL Trial Explained
No effect on cancer incidence, but 25% reduction in cancer mortality. Why the target level matters more than the dose.
🔬 Grade B: PromisingExercise as Cancer Prevention
20-30% reduced risk of colon, breast, and endometrial cancers. One of the most consistent signals in prevention research.
⭐ Grade A: Strong EvidenceFasting and Caloric Restriction
Reduces IGF-1 and insulin, activates autophagy. Animal data is strong. Human data is promising but limited.
🔶 Grade C: Early / LimitedRapamycin for Cancer Prevention
mTOR inhibition: the most compelling biology with the biggest evidence gap. Prescribed off-label by longevity physicians.
🔶 Grade C: Early / LimitedAspirin for Colorectal Cancer
Real 10-19% risk reduction. But the ASPREE trial complicated things for older adults. Age and timing matter.
🔬 Grade B: PromisingGreen Tea (EGCG)
Japanese cohort studies show 20-30% reduced cancer risk. Phase II data in prostate cancer. The cancer prevention beverage.
🔬 Grade B: PromisingBest Cancer Prevention Supplements 2026
Every supplement ranked by human evidence. Tier 1 (take these), Tier 2 (promising), and what to avoid.
📊 Evidence-Ranked Guide